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Melioidose

Zuletzt geändert von Thomas Brinkmeier am 2025/04/25 20:44

Melioidose

Syn: Pseudomalleus

Engl: Melioidosis, Whitmore disease, Stanton's disease

Histr: Erstbeschreibung durch Whitmore und Krishnaswami im Jahre 1912

Def: in Südostasien endemische Tropeninfektion mit gramnegativem Bakterium

Err: Pseudomonas pseudomallei

Syn: Burkholderia pseudomallei

Inf: Infektion aerogen oder über kleine Hautverletzungen bei Kontakt mit erregerhaltiger Erde in Reisanbaugebieten

KL: ähnlich dem Malleus

Di: - Kultur aus Blut, Sputum oder infektiösem Gewebe

- Serologie

Th: Ceftazidim

Bed: GS

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Dos: 120 mg/kg/Tag i.v. für mind. 8 Wochen

Altn: Kombinationstherapie aus Doxycyclin und Trimethoprim/Sulfamethoxazol

Stoff: - Doxycyclin

Dos: 2x100 mg/Tag

- Trimethoprim/Sulfamethoxazol

Dos: 10/50 mg/kg/Tag

  
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