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Antihistaminika

Zuletzt geändert von Thomas Brinkmeier am 2025/04/25 21:46

Antihistaminika

NW: - Sedation

- anticholinerge NW

Bed: von klinischer Relevanz meist nur bei den älteren "klassischen" Präparaten

Bsp: Mundtrockenheit, Obstipation, Augendruckerhöhung, Miktionsstörungen

- Intoxikation

KL: Flush, weite Pupillen, Temperaturanstieg, Halluzinationen, Krämpfe

Th: Diazepam

WW: mit anderen Medikamenten, die über Cytochrom P450 abgebaut werden:

Stoff: - Makrolide

- Barbiturate

- Cyclosporin A

- Phenytoin

- Imidazole

- Antiarrhythmika

- Kontrazeptiva

Etlg: - H1-Blocker

Ind: allergische und/oder pruriginöse Dermatosen

Stoff: Auswahl:

- Alimemazin

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NW: sedierend, neuroleptisch

- Antazolin

- Azelastin

OTC: Allergodil®, Vividrin®, Azela-Vision® sine (unkonservierte Einzeldosen), Azela-Vision® MD sine (6 ml Tropfen-System, unkonserviert)

- Bilastin

- Cetirizin

OTC: Cetiricin® ADGC Tbl., Cetiderm® Tbl., Cetirizin AZU®, Cetirizin Sandox® Sirup, Cetirizin-ratiopharm® Saft, Zyrtec® Tbl./Tropfen/Saft

Co: Pseudoephedrin

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- Clemastin

OTC: Tavegil®

NW: sedierend

- Cyproheptadin

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- Desloratadin

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Co: Pseudoephedrin

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- Dimetinden

OTC: Fenistil® Tropfen/Sirup/24 h ret Kps./Injektions-Lsg.

- Ebastin

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- Fexofenadin

Def: Metabolit von Terfenadin

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- Hydroxyzin

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NW: anticholinergisch, sedierend

- Ketotifen

OTC: Zaditen®

- Levocabastin

OTC: Livocab®

- Levocetirizin

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Note: ähnliches Sedierungsprofil wie Cetiricin

Lit: Ann Allergy Asthma Immunol. 2011 Dec;107(6):517-22.

- Loratadin

OTC: Loratadin® ADGC Tbl., Loraderm®, Loratadin AZU®

- Mizolastin

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- Rupatadinfumarat

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Wirk: zusätzliche Hemmung des platelet acitving factors (PAF)

Ind: auch bei kutanen Mastozytosen mit symptomatischer Besserung

Lit: Allergy. 2013 Jun 4. http://doi.org/10.1111/all.12159 (Berlin)

PT: RCT

- Terfenadin

Neg: kardiale NW

- H2-Blocker

Ind: allergische Dermatosen und als Magenschutz (insbes. bei Steroidtherapie)

Stoff: - Ranitidin

- Cimetidin

  
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