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Dabrafenib

Zuletzt geändert von Thomas Brinkmeier am 2021/06/13 20:11

Dabrafenib

Ind: nicht resezierbares oder metastasiertes Melanom

Vor: Nachweis der Punktmutation V600E bei B-RAF (Austausch von Valin gegen Glutaminsäure am Codon 600)

Vork: ca. 50% d. F.

Wirk: - selektive BRAF-Hemmung (reversibel und konkurrierend mit ATP um die Bindungsstelle)

- auch intrakraniell wirksam

NW: Cephalgien, Fieber, Palmoplantarkeratosen, aber - im Vergleich zu Vemurafenib - vergleichsweise selten Phototoxizität, Exantheme, Arthalgien und Müdigkeit/Abgeschlagenheit

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Bed: progressionsfreies Überleben 6,9 Monate (DTIC: 2,7 Monate), Ansprechrate von 53% (40% partielle Remission, 3% komplette Remission)

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