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Epitheloides Sarkom

Zuletzt geändert von Thomas Brinkmeier am 2025/04/25 20:45

Epitheloides Sarkom

Syn: epitheloides Sarkom, Epitheloidsarkom

Engl: epithelioid sarcoma

Def: maligner Bindegewebstumor, von Sehnenscheiden ausgehend (Entartung pluripotenter mesenchymaler Zellen)

Vork: meist jüngere Männer

Lok: meist akral; Prädilektionsstelle: Unterarm mit Hand, Unterschenkel, Kopfhaut

KL: relativ langsam wachsender subkutaner harter Knoten, teils mit sporotrichoider Ausbreitung per continuitatem entlang der Gewebslogen (Sehnen, Nerven) oder auch in ringförmiger Anordnung oder als nicht abheilendes, indolentes Ulkus

Hi: kuboidale (epitheloide) Tumorzellen, teils granulomartig mit zentraler Nekrose

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DD: Granuloma anulare

IHC: Zytokeratin, Vimentin

Prog: schlecht

Filia: v. a. Lunge

DD: Verruca vulgaris, Fremdkörpergranulom

Lit:  

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Th: Exzision mit weitem SA

Co: Chemotherapie, Radiatio

Altn: - Amputation

- Polychemotherapie

Ind: Metastasierung

  
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