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Papuloerythrodermie Ofuji

Zuletzt geändert von Thomas Brinkmeier am 2025/04/25 21:38

Papuloerythrodermie Ofuji

Histr: Erstbeschreibung durch Ofuji im Jahre 1984

Vork: meist ältere Männer

HV: stark juckende, dicht stehende, aber nicht konfluierende rötliche Papeln mit charakteristischer Aussparung der Hautfalten ("deck chair sign")

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DD: weitere Dermatosen mit möglichem "deck chair sign": Angioimmunoblastisches T-Zell-Lymphom, großherdige Parapsoriasis, Makroglobulinämie Waldenström, Imatinib-induzierte exfoliative Dermatitis, diffuse Lepra, Parthenium-Dermatitis (Korbblütler, sog. Mutterkraut)

Hi: subakute Dermatitis mit dichten, superfiziellen, lymphohistiozytären und eosinophilenreichen perivaskulär betonten Infiltraten

Lab: Eosinophilie, Lymphopenie und erhöhtes IgE

Ass: - verschiedene entzündliche Dermatosen, insbes. atopische Dermatitis und Psoriasis

- Lymphadenopathie

- Malignome, insbes. Lymphome

- HIV, Hepatitis C

- Arzneimittel

Kopl: Entwicklung eines malignen kutanen Lymphoms, insbes. Mycosis fungoides

So: paraneoplastisches Auftreten

Lit:  

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Note: Wahrscheinlich existieren abortive Formen

Lit: Eur J Dermatol 2003; 13: 272-5

EbM: keine CT

Th: - UV-Therapie

Bed: GS

Meth: insbes. PUVA

Co: Retinoide (RePUVA), Interferon

- Glukokortikoide

Appl: lokal/systemisch

Altn: - Cyclosporin A, Azathioprin

- MTX

Lit: Dermatol Ther. 2020 Jan 8:e13219. htttp://doi.org/10.1111/dth.13219, Clin Exp Dermatol. 2019 May 21. http://doi.org/10.1111/ced.13997

- Dupilumab

Co: UV-Therapie

Lit: Australas J Dermatol. 2023 Aug;64(3):e241-e244. http://doi.org/10.1111/ajd.14078

Lit: - JAMA Dermatol. 2019 Jun 19. http://doi.org/10.1001/jamadermatol.2019.0946

- J Eur Acad Dermatol Venereol. 2020 May 7. http://doi.org/10.1111/jdv.16581

- Case Rep Dermatol. 2022 May 23;14(2):117-122. http://doi.org/10.1159/000524716

  
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